Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue
نویسندگان
چکیده
منابع مشابه
Brown adipose tissue and thermogenesis.
The growing understanding of adipose tissue as an important endocrine organ with multiple metabolic functions has directed the attention to the (patho)physiology of distinct fat depots. Brown adipose tissue (BAT), in contrast to bona fide white fat, can dissipate significant amounts of chemical energy through uncoupled respiration and heat production (thermogenesis). This process is mediated by...
متن کاملLack of TRPV2 impairs thermogenesis in mouse brown adipose tissue.
Brown adipose tissue (BAT), a major site for mammalian non-shivering thermogenesis, could be a target for prevention and treatment of human obesity. Transient receptor potential vanilloid 2 (TRPV2), a Ca(2+)-permeable non-selective cation channel, plays vital roles in the regulation of various cellular functions. Here, we show that TRPV2 is expressed in brown adipocytes and that mRNA levels of ...
متن کاملCentral Control of Brown Adipose Tissue Thermogenesis
Thermogenesis, the production of heat energy, is an essential component of the homeostatic repertoire to maintain body temperature during the challenge of low environmental temperature and plays a key role in elevating body temperature during the febrile response to infection. Mitochondrial oxidation in brown adipose tissue (BAT) is a significant source of neurally regulated metabolic heat prod...
متن کاملHypothalamic control of brown adipose tissue thermogenesis
It has long been known, in large part from animal studies, that the control of brown adipose tissue (BAT) thermogenesis is insured by the central nervous system (CNS), which integrates several stimuli in order to control BAT activation through the sympathetic nervous system (SNS). SNS-mediated BAT activity is governed by diverse neurons found in brain structures involved in homeostatic regulati...
متن کاملMechanisms of thermogenesis in brown adipose tissue.
In 1969, Rafael and colleagues observed that the uncoupled state of mitochondria prepared from the brown fat of newborn guinea pigs could be reversed by incubation in the presence of albumin and certain purine nucleotides (Rafael et al., 1969). In 1974, we showed that this uncoupled state was due to the presence in the inner membrane of the mitochondria of a regulatable ion conductance pathway,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Reports
سال: 2019
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2019.02.015